Pre-Habilitation with Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)

This study — called the PRIMER Trial — is testing whether a combination of mindfulness practice and exercise before bladder removal surgery (radical cystectomy) can improve patients' physical fitness and quality of life. Preparing the body and mind before major surgery is called "pre-habilitation," and researchers believe it can lead to better recovery outcomes. **You may be eligible if...** - You are 18 or older - You have been diagnosed with bladder cancer requiring radical cystectomy (bladder removal) - Your surgeon has deemed you a good surgical candidate - You are willing to engage in both an exercise program and mindfulness practices before your surgery - You can communicate in English or Spanish **You may NOT be eligible if...** - You have contraindications to aerobic exercise - You currently participate in a regular aerobic exercise program - You have new chest pain or shortness of breath with exertion - Your bladder cancer is of a rare, aggressive subtype (micropapillary or sarcomatoid) - Your cancer has spread to distant organs Talk to your doctor to see if this trial is right for you.