Study of the Medullary Microenvironment in Acute Childhood Leukemia

This study is examining the bone marrow environment in children with acute leukemia (blood cancer) to understand what conditions allow cancer cells to survive and grow. By comparing bone marrow samples from children with leukemia to samples from healthy children having bone surgery, researchers hope to find new targets for treatment. **You may be eligible if...** - You are a child between 1 and 15 years old - You have been newly diagnosed with acute lymphoblastic or myeloblastic leukemia (no prior hematological treatment) - OR you are a child (1–15 years) undergoing hip or pelvic bone surgery with no blood disorder (as a healthy comparison) - A parent or guardian has provided informed consent **You may NOT be eligible if...** - The child is younger than 1 year or older than 15 years - The child's leukemia is a relapse (has come back) - The child has received prior blood cancer treatments - There is a contraindication to bone marrow sampling - A parent's condition prevents them from understanding or signing the consent form Talk to your doctor to see if this trial is right for you.