RecruitingNot ApplicableNCT05795634

Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease

Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease (Stress-AD)


Sponsor

Johns Hopkins University

Enrollment

240 participants

Start Date

Mar 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn about how genetics and the response to stress predicts cognitive decline in individuals with mild cognitive impairment. The main question\[s\] it aims to answer are: * Does the hormone response to acute stress predict the degree of cognitive impairment following acute stress? * Do genes associated with the risk for Alzheimer's disease influence the relationship between stress hormone response to stress and cognitive impairment following stress? * Do cognitive impairment following acute stress and genes associated with the risk for Alzheimer's disease predict cognitive decline and change in biomarkers for Alzheimer's disease 2 years later? Participants will have 3 in-person study visits. The first 2 will occur at baseline and the 3rd visit will occur 2 years later. During the visits, participants will provide blood and saliva samples, undergo a 10-minute social stress procedure, complete questionnaires, and take tests of memory and other thinking skills. Someone who knows the participant (a "study partner") will be asked questions about the participant's daily functioning at the first and 3rd study visits.


Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how stress affects thinking and memory in older adults who show early signs of cognitive decline (mild cognitive impairment, or MCI), with a follow-up visit two years later to track changes. **You may be eligible if...** - You are 60 or older - You are a fluent English speaker - You meet clinical criteria for mild cognitive impairment (MCI) - You are able to return for a 2-year follow-up visit - You can provide the name of a family member or close contact who can also participate in the screening - Your BMI is between 17 and 30 **You may NOT be eligible if...** - You do not meet the clinical criteria for MCI - You are unable to arrange a 2-year follow-up or provide an informant - Other medical or cognitive conditions apply Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALTrier Social Stress Test

Acute psychosocial stress procedure; 5 minutes of public speaking and 5 minutes of mental arithmetic


Locations(1)

Johns Hopkins School of Medicine

Baltimore, Maryland, United States

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NCT05795634


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