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RecruitingPhase 3NCT05796973

Measuring Oncological Value of Exercise and Statin

Syöpäpotilaan Ennusteen Parantaminen Muuttamalla syövän mikroympäristöä ja Metaboliaa Liikunnalla ja lääkkeellisesti - Measuring Oncological Value of Exercise and Statin

Sponsor

Tampere University Hospital

Enrollment

240 participants

Start Date

Mar 31, 2023

Study Type

INTERVENTIONAL

Conditions

Breast CancerMetastatic Breast CancerOvarian CancerProstate CancerMetastatic Renal Cell CarcinomaMetastatic Ovarian CancerMetastatic Prostate CancerKidney CancerMetastatic Kidney CancerMetastatic Renal CancerMetastatic Prostate AdenocarcinomaMetastatic Ovary Cancer

Summary

The aim of the study is to find out whether supervised physical exercise during cancer drug treatment improves the effectiveness of the treatment in metastasized breast, kidney, ovarian and prostate cancer compared to unsupervised exercise. In addition, the investigators are investigating whether the use of atorvastatin combined with guided group exercise training would further improve the response to cancer treatment.

Eligibility

Min Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether combining exercise and a statin medication (a cholesterol-lowering drug that may also slow cancer growth) can improve outcomes in patients with metastatic prostate, breast, ovarian, or kidney cancer who are starting first-line drug treatment. **You may be eligible if...** - You have metastatic prostate cancer (starting docetaxel or a second-generation antiandrogen), breast cancer (starting first-line treatment), ovarian cancer, or kidney cancer — each starting first-line medical treatment - Your cancer diagnosis is confirmed by tissue and imaging **You may NOT be eligible if...** - You are not starting a first-line cancer treatment - You have another cancer type not listed - Other health criteria apply (your doctor will review) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALGuided physical exercise

Patients will be participating in guided physical exercise program regularly two times / week at a sports facility and guided by a professional trainer. They will participate in aerobic and resistance exercises during the sessions.

DRUGAtorvastatin

Patients will be participating in guided physical exercise program regularly two times / week at a sports facility and guided by a professional trainer. They will participate in aerobic and resistance exercises during the sessions. In addition to the exercise program they will be given atorvastatin 40 mg QD medication.

OTHERIndependent exercise

The control group is advised of the benefits of physical exercise and they get an exercise program to follow. Participants in the control group exercise on their own.

Locations(1)

Tampere University Hospital

Tampere, Länsi-Suomi, Finland

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NCT05796973

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