RecruitingPhase 4NCT05805436

Preop Laxatives in Robotic Urologic Surgery

The Use of Preoperative Osmotic Laxatives to Improve Recovery of Bowel Function After Robotic-assisted Urologic Surgery


Sponsor

Chad R. Tracy

Enrollment

240 participants

Start Date

Jun 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Minimally-invasive surgery, either laparoscopic or robotic, is commonly used in urology. Several urologic procedures including prostatectomy, radical nephrectomy, and partial nephrectomy are now commonly performed robotically. Patients undergoing these procedures often have delayed return of bowel function and persistent gastrointestinal symptoms including nausea/vomiting, abdominal distension, and bloating for several days to weeks after surgery. Postoperative stool softeners and laxatives are routinely used in an effort to minimize these symptoms, with varying degrees of success. The aim of this study will be to evaluate whether the use of a preoperative osmotic laxative will be beneficial in improving recovery of bowel function and alleviating postoperative gastrointestinal complaints in patients undergoing these procedures. Patients will be randomized to either receive or not receive three days of polyethylene glycol (PEG, also known as MiraLAX) on the three days before surgery. Patients in both groups will receive the same postoperative bowel regimen including scheduled PEG both in the hospital and upon discharge until first bowel movement. Patients will be given a questionnaire and diary to record their postoperative gastrointestinal symptoms and time to first bowel movement. These questionnaires and diaries will then be analyzed to determine differences in time to first bowel movement and gastrointestinal complaints during their recovery from surgery.


Eligibility

Min Age: 30 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether giving a laxative (polyethylene glycol/Miralax) before robotic-assisted urological surgery — such as prostate removal or kidney surgery — reduces complications and improves recovery. Specifically, it looks at whether clearing the bowel beforehand helps when the surgeon is working near the intestines. **You may be eligible if:** - You are 30 years or older - You are scheduled for a robotic-assisted prostatectomy (prostate removal), radical nephrectomy (kidney removal), or partial nephrectomy (partial kidney removal) through the abdomen **You may NOT be eligible if:** - You are under 30 years old - You already regularly take Miralax - You are allergic to or cannot take polyethylene glycol or laxatives - You are having retroperitoneal (behind the abdomen) kidney surgery - You have severe ulcerative colitis or Crohn's disease - You have a colostomy or ileostomy - You have had prior abdominal or pelvic radiation - You are incarcerated Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPolyethylene Glycol 3350

Patients in the intervention arm will take polyethylene glycol 3350 for three days before robotic urologic surgery. Patients in the control arm will not.


Locations(1)

University of Iowa Hospitals & Clinics

Iowa City, Iowa, United States

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NCT05805436


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