RecruitingNot ApplicableNCT05813093

Interleaved TMS-fMRI in Ultra-treatment Resistant Depression

Interleaved TMS-fMRI to Evaluate Intermittent Theta-burst and Dorsolateral Prefrontal Circuit Engagement in Ultra-treatment Resistant Depression

Sponsor

Sunnybrook Health Sciences Centre

Enrollment

88 participants

Start Date

Sep 27, 2023

Study Type

INTERVENTIONAL

Conditions

Major Depressive Disorder

Summary

This is a study that will recruit patients from the neurosurgery clinic and the regular TMS clinic. It's a smaller study designed to collect brain imaging pre-treatment and then use image guided TMS to treat patient with a one week "accelerated" rTMS protocol using the research TMS machine that is housed in Dr. Sean Nestor's lab. The idea is to examine whether severe treatment resistant depression has a different brain signature than less severe/TRD and whether the investigators can get a therapeutic response from patients that would otherwise undergo neurosurgery or will ultimately undergo neurosurgery.

Eligibility

Min Age: 20 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This trial is using an advanced brain imaging technique (TMS combined with fMRI) to understand brain activity patterns in people with ultra-treatment-resistant depression — those who have tried many antidepressants without improvement — to help guide better treatments. **You may be eligible if...** - You are between 20 and 65 years old - You have a diagnosis of major depressive disorder or persistent depressive disorder with a current moderate-to-severe episode - Your depression symptoms have lasted 5 or more years - You have tried and failed at least 6 antidepressants (including at least 1 add-on medication) at adequate doses - Your depression score on the Hamilton Rating Scale is 18 or above **You may NOT be eligible if...** - You have responded to antidepressant treatment - You are outside the 20–65 age range - You have a pacemaker or metal implants incompatible with MRI - You have active psychosis or other conditions that interfere with brain imaging Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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