RecruitingNot ApplicableNCT06159595

Behavioral and Neuronal Correlates of Human Mood States

Sponsor

Stanford University

Enrollment

10 participants

Start Date

Dec 1, 2023

Study Type

INTERVENTIONAL

Conditions

Epilepsy Major Depressive Disorder

Summary

Optimizing treatments in mental health requires an easy to obtain, continuous, and objective measure of internal mood. Unfortunately, current standard-of-care clinical scales are sparsely sampled, subject to recency bias, underutilized, and are not validated for acute mood monitoring. The recent shift to remote care also requires novel methods to measure internal mood. Recent advances in computer vision have allowed the accurate quantification of observable speech patterns and facial representations. The continuous and objective nature of these audio-facial behavioral outputs also enable the study of their neural correlates. Here, the investigators hypothesize that video-derived audio-facial behaviors have discrete neural representations in the limbic network and can provide a critical set of reliable longitudinal estimates of mood at low cost across home and clinic settings.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This research study is investigating the brain activity and behavior associated with different mood states — especially depression — in patients with major depressive disorder. It involves implanting small electrodes in the brain to directly record neural activity and understand what happens in the brain during mood changes. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with major depressive disorder and are currently in a depressive episode (confirmed by structured psychiatric interview) - You do not have any medical or surgical reason that would make brain electrode implantation unsafe - You are capable of understanding the study and providing informed consent **You may NOT be eligible if...** - You are outside the age range of 18 to 65 - You are not currently in a major depressive episode - You have a medical condition that makes brain surgery unsafe - You are unable to understand or consent to the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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