Coronary CT-Derived FFR-Guided Strategy Versus Medical Therapy
Coronary Computed Tomography-Derived Fraction Flow Reserve (FFR)-Guided Invasive Treatment Strategy (ITS) Versus Optimal Medical Therapy (OMT) Alone in Patient With Chronic Coronary Syndrome
Second Affiliated Hospital, School of Medicine, Zhejiang University
1,066 participants
Oct 10, 2024
INTERVENTIONAL
Conditions
Summary
The overall purpose of ACCURATE II trial is to compare the clinical outcomes of CT-derived FFR guided strategy versus medical therapy in patients with chronic coronary syndrome.
Eligibility
Inclusion Criteria3
- Age ≥ 18 years, with at least one vessel has CT-derived FFR≤0.80
- Patients with chronic coronary syndromes
- Signed written informed consent
Exclusion Criteria9
- The patient has a known hypersensitivity or contraindication to any of the following medications: Heparin, Aspirin, Clopidogrel, Prasugrel, Ticagrelor, Contrast media (Patients with documented sensitivity to contrast media which can be effectively pre-medicated with steroids and diphenhydramine \[e.g. rash\] may be enrolled)
- Prior percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)
- Sinus arrhythmia, cardiogenic shock, or severe heart failure (NYHA≥III)
- Inability or unwillingness to undergo CT scan or coronary angiography
- Patients on hemodialysis or with severe hepatic or renal insufficiency
- Left main coronary artery stenosis ≥ 50%
- Target vessel total occlusion
- Pregnancy or intention to become pregnant during the course of the trial
- Patients with a life expectancy less than 2 years
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Interventions
Invasive treatment strategy plus optimal medical therapy
Optimal medical therapy alone
Locations(1)
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NCT05824520