Interval Cytoreductive Surgery With or Without HIPEC for Ovarian Cancer (FOCUS / KOV-HIPEC-04)

This trial is studying whether adding a heated chemotherapy wash directly into the abdomen (called HIPEC) during interval surgery improves survival in women with advanced ovarian cancer who have already received three cycles of chemotherapy before surgery. **You may be eligible if...** - You are 18–79 years old - You have been diagnosed with advanced (stage III–IV) ovarian, fallopian tube, or primary peritoneal cancer confirmed by biopsy - You have completed three cycles of neoadjuvant chemotherapy - You have had or are scheduled for interval cytoreductive (debulking) surgery that achieved complete or near-complete removal of visible tumors - Your organ function is adequate for major surgery **You may NOT be eligible if...** - You have a non-epithelial ovarian cancer or a borderline tumor - You did not receive neoadjuvant chemotherapy - Your surgery left significant residual tumor (more than 2.5 mm depth) - You have a life expectancy of 3 months or less - You have another cancer diagnosed within the past 5 years (with limited exceptions) - You have active infections, active tuberculosis, or central nervous system metastases Talk to your doctor to see if this trial is right for you.