RecruitingNCT05833828
Differential Regulation of RAAS-axis in Patients Undergoing Cardiac Surgery
Differences in Plasma Concentration of RAAS-axis Hormones in Patients Undergoing Cardiac Surgery With or Without Cardiopulmonary Bypass
Sponsor
Universität Münster
Enrollment
40 participants
Start Date
Aug 24, 2023
Study Type
OBSERVATIONAL
Conditions
Summary
This study investigates the question of whether there are differences in the plasma concentration of hormones of the RAAS-axis between patients undergoing on-pump cardiac surgery and those receiving off-pump surgery
Eligibility
Min Age: 18 Years
Inclusion Criteria2
- adult patients undergoing on- or off-pump coronary artery bypass graft surgery
- written informed consent
Exclusion Criteria8
- emergency surgery in the context of acute coronary syndrome
- ACE-inhibitor or Angiotensin 1 (AT1)-receptor-blocker intake that was not paused on the day of surgery
- Chronic kidney disease with estimated glomerular filtration rate (eGFR)\<30ml/min/1.73m²
- Severe structural lung disease (asbestosis, silicosis, severe sarcoidosis, tuberculosis, severe emphysema, chronic obstructive pulmonary disease (COPD) Gold 3-4, lung fibrosis)
- Chronic pulmonary hypertension
- Pregnancy or breastfeeding
- Persons with any kind of dependency on the investigator or employed by the institution responsible or investigator
- Persons held in an institution by legal or official order
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Interventions
PROCEDUREon-pump surgery
the surgery will be performed "on-pump"
PROCEDUREoff-pump surgery
the surgery will be performed "off-pump"
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT05833828
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