Characterisation of Endothelial Cells in Different Inflammatory Pathologies
Royal Surrey County Hospital NHS Foundation Trust
105 participants
Jul 16, 2024
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to characterise changes in gene expression in endothelial cells in patients with either sepsis or post major abdominal surgery. The main question we plan to answer is: 'What molecular pathways are differentially expressed during inflammatory pathologies?'
Eligibility
Inclusion Criteria10
- Healthy volunteer
- Adult ≥ 18 years
- Able and willing to give consent
- Surgical patients
- Adult ≥ 18 years
- Patients admitted to RSFT for planned major surgery
- Critically ill patients
- Adult ≥ 18 years
- Emergency admission to ICU at RSFT
- Meets the sepsis 3.0 definition
Exclusion Criteria19
- Healthy volunteer
- Not currently a patient within the hospital
- Absence of inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, diabetes, cardiovascular disease and CKD.
- Not on immunomodulatory medications, such as corticosteroids
- History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation)
- Surgical patients
- Patients with restricted liberty, prisoners or under legal protection
- Anticipated prohibitively difficult venous cannulation
- Presenting with inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, sepsis, diabetes with end organ damage, cardiovascular disease and CKD
- Currently prescribed immunomodulatory medication or immunocompromised
- Received chemotherapy within 2 weeks of predicted sampling
- Receiving vasopressor support prior to surgery
- History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation)
- Critically ill patients
- Patients with restricted liberty, prisoners or under legal protection• Anticipated prohibitively difficult venous cannulation
- Presenting with inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, diabetes with end organ damage, cardiovascular disease and CKD.
- Currently prescribed immunomodulatory medication or immunocompromised
- Received chemotherapy within 2 weeks of predicted sampling.
- History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation)
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Interventions
Endothelial cell sample collected from the antecubital fossa of patients. A vein in the antecubital fossa is cannulated with a 20 g valveless cannula. A metal guidewire is then passed into the vessel to collect endothelial cells for analysis
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06613256