Effects of Percutaneous Transluminal Renal Angioplasty of Atherosclerotic Renal Artery Stenosis in High-Risk Patients.

This study is testing whether a minimally invasive procedure to open up a narrowed kidney artery (called renal angioplasty with stenting) helps people with both severe kidney artery blockage AND difficult-to-control blood pressure, rapidly declining kidney function, or recurrent heart failure episodes. Standard medical management alone often falls short for these high-risk patients. **You may be eligible if...** - You have been found to have a significant kidney artery narrowing (70% or more blockage) confirmed by angiography - You also have at least one of: blood pressure that cannot be controlled on 3+ medications, rapidly worsening kidney function, or repeated hospitalizations for sudden heart failure ("flash" pulmonary edema) **You may NOT be eligible if...** - You have had prior kidney artery stenting - You have had a kidney transplant - Your kidney is very small (less than 7 cm) - Your kidney artery narrowing is due to a non-hardening-of-the-arteries cause (e.g., fibromuscular dysplasia) - You are pregnant Talk to your doctor to see if this trial is right for you.