MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans With Severe Posttraumatic Stress Disorder

This study is comparing two treatments for veterans with severe PTSD (post-traumatic stress disorder): standard Cognitive Processing Therapy (CPT) versus MDMA-assisted Cognitive Processing Therapy — where a controlled, supervised dose of MDMA (the active compound in ecstasy) is combined with the therapy. The goal is to see whether MDMA can help make trauma therapy more effective for those with the most severe PTSD. **You may be eligible if...** - You are a U.S. Military Veteran aged 18 or older - You receive care at one of three VA healthcare systems in the Bay Area / NorCal - You have been diagnosed with PTSD for at least 6 months with severe current symptoms - You weigh at least 48 kg (about 106 lbs) - You are not pregnant and not planning to become pregnant - You can identify a support person to stay with you after MDMA sessions **You may NOT be eligible if...** - You have heart conditions, uncontrolled hypertension, or certain other medical conditions that make stimulant drugs dangerous - You have a history of psychosis, bipolar I disorder, or severe personality or eating disorders - You have ever used MDMA (ecstasy) before - You have moderate or severe alcohol or drug use disorder in the past year - You have had ECT or ketamine therapy in the past 12 weeks Talk to your doctor to see if this trial is right for you.