Efficacy and Accuracy of Combined Localization Versus Single Localization in Non-palpable Breast Cancer After Neoadjuvant Therapy

This study compares two methods of marking a breast cancer tumor before surgery for women whose tumor shrank or became non-palpable (unable to be felt) after chemotherapy given before surgery. The goal is to see if using a combination of localization techniques is better than just one method at guiding surgeons to remove the right tissue. **You may be eligible if...** - You are a woman aged 18 or older - You were diagnosed with breast cancer confirmed by a needle biopsy - Your tumor became non-palpable after neoadjuvant (pre-surgery) chemotherapy - You are willing and able to have breast-conserving (lumpectomy) surgery **You may NOT be eligible if...** - You have inflammatory breast cancer or Paget's disease - You have breast deformities that make localization techniques impractical - You are unable to have breast-conserving surgery for medical reasons Talk to your doctor to see if this trial is right for you.