RecruitingPhase 3NCT05841056

Short Term Anti-aRrhythmic Therapy for Post-Operative AF in Cardiac Surgery Patients Pilot Trial

Short Term Anti-aRrhythmic Therapy for Post-Operative AF in Cardiac Surgery Patients (START-POAF) Pilot Trial


Sponsor

Population Health Research Institute

Enrollment

400 participants

Start Date

Jun 13, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The START-POAF pilot study is a prospective, open-label two-arm, randomized controlled trial with blinded assessment of outcomes (PROBE). This pilot study will assess Atrial Fibrillation (AF) recurrence and burden in patients with new-onset AF following cardiac surgery.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This pilot study looks at how long patients should take anti-arrhythmic medication (amiodarone) after developing a new irregular heartbeat called atrial fibrillation following cardiac surgery. Atrial fibrillation is common after heart surgery and usually resolves on its own, but the ideal duration of medication treatment is uncertain. **You may be eligible if...** - You are 18 or older - You recently had cardiac surgery (bypass, valve, or aorta surgery) within the past 14 days - You developed a new episode of atrial fibrillation or flutter after surgery, confirmed by ECG - You are expected to be discharged from the hospital within 48 hours of entering the study **You may NOT be eligible if...** - You had atrial fibrillation before surgery - You are pregnant or breastfeeding - You have severe thyroid, liver, or lung disease - You cannot safely take amiodarone due to a serious reaction or medical contraindication Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAmiodarone Hydrochloride 200 MG

200 mg daily for 4 weeks


Locations(1)

Hamilton General Hospital

Hamilton, Ontario, Canada

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NCT05841056


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