RecruitingPhase 2NCT05845723

Tocilizumab and Tofacitinib in the Treatment of Vascular Behçet's Syndrome

Efficacy and Safety of Tocilizumab and Tofacitinib in the Treatment of Patients With Vascular Behçet's Syndrome

Sponsor

Peking Union Medical College Hospital

Enrollment

81 participants

Start Date

Jun 1, 2023

Study Type

INTERVENTIONAL

Conditions

Aneurysm Behcet Syndrome, Vascular Type

Summary

This project aims to evaluate the efficacy and safety of the combination of glucocorticoids with tocilizumab or tofacitinib, compared to the traditional combination of glucocorticoids with cyclophosphamide in the treatment of vascular Behçet's syndrome.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called cyclophosphamide, a drug called tocilizumab, and others for people with aneurysm and behcet syndrome, vascular type. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 65 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGtocilizumab

Participants will receive intravenous infusion of tocilizumab 8mg/kg every 4 weeks for 24 weeks.

DRUGtofacitinib

Participants will receive tofacitinib 5mg twice a day for 24 weeks of treatment.

DRUGcyclophosphamide

Participants will receive intravenous infusion of cyclophosphamide 0.5g biweekly for 24 weeks.

Locations(1)

Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

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NCT05845723

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