RecruitingNot ApplicableNCT05848973

NutriMind: A Combination of Healthy Diet and Psychotherapy to Treat Depression

The NutriMind Trial: A Low-cost Randomized Trial Combining a Healthy Diet and Psychotherapy to Treat Depressive Symptoms Among University Students - The Case of Uganda


Sponsor

University of Bergen

Enrollment

500 participants

Start Date

Jan 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

University students in Low- and Middle-Income Countries (LMIC) continue to face growing rates of depression, a common mental health problem. Adding to this burden is the mental health treatment gap, necessitating the need to identify new treatment methods that can easily be implemented at a large scale. This project will test if a healthy diet combined with mindfulness-based cognitive therapy can reduce depressive symptoms among university students in Uganda, a low resource country. The burden of depression is high in sub-Saharan African countries, largely worsened by poverty, hunger and poor public health service, and lately the COVID-19 pandemic. These factors increase psychological distress among young people in sensitive periods of life, such as students who are about to choose their career and establish family. Successfully managing depression in LMIC is likely to depend on low-cost treatment that can easily be managed to large target populations, yet still be at the scientific forefront, proof-based, and culturally acceptable. This can possibly be obtained with an intervention combining healthy diet and cognitive behavioral therapy based on mindfulness principles. While healthy diets and mindfulness cognitive therapy individually can partly lessen the burden of depression, these two therapeutic modalities have not been tested in combination among university students in sub-Saharan Africa, i.e. a synergistic effect that is still to be studied. With the NutriMind Trial, its investigators focus on a neglected global mental health challenge, namely depression among university students in Uganda.


Eligibility

Plain Language Summary

Simplified for easier understanding

This study is testing whether a combination of healthy eating coaching and psychotherapy (talk therapy) can reduce depression symptoms in university students. The program, called NutriMind, is designed to improve both mental health and diet quality at the same time. **You may be eligible if...** - You are a university student who has completed at least one year of study and has at least two more years before graduating - Your depression score on a standard screening questionnaire falls in the mild-to-moderate range - You are not currently taking medications that might interfere with the study **You may NOT be eligible if...** - You have severe depression requiring immediate clinical treatment - You are currently taking medications regularly that could affect your mood or diet adherence - You have less than two years remaining in your degree - You are unwilling to give consent or follow the study program Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERHealthy Diet

The targeted study participants will be given advice about healthy dietary intakes. This will entail promotion of foods rich in vegetables/fruits and wholegrain/fibre, fish, olive oil; moderate in lean red meat and low-fat diary products). To be concrete, the study investigators will target energy (E%) from macronutrients as follows: 42 E% total fat (≥ 22 E% from monounsaturated fatty acids, 10 E% from polyunsaturated fatty acids and \<10 E% saturated fatty acids), 35 E% carbohydrate, 15 E% protein and ≤ E 5% alcohol. Importantly, this will meet all Recommended Dietary Intake requirements for adults.

BEHAVIORALMindfulness-based cognitive therapy (MBCT)

MBCT is a skills-based intervention comprising a structured 8-week group intervention program to be delivered in groups of study participants, with an all-day practice session around week six and regular reunion sessions thereafter.


Locations(1)

Makerere University

Kampala, Central Uganda, Uganda

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NCT05848973


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