Dexmedetomidinine in the Prevention of Postoperative Delirium in the Intensive Care Unit After Cardiac Surgery
University of Novi Sad
200 participants
Mar 1, 2022
INTERVENTIONAL
Conditions
Summary
This is a prospective, randomized, single blinded, controlled clinical trial designed to compare the clinical effects of sedation with dexmedetomidine versus propofol in patients undergoing cardiac surgery.
Eligibility
Inclusion Criteria2
- patients undergoing open heart surgery with the use of cardiopulmonary bypass (including coronary artery bypass grafting, valve repair/replacement, and combined)
- left ventricular ejection fraction (LVEF) >40%.
Exclusion Criteria8
- preoperative atrial fibrillation
- previous history of interventionally treated arrhythmias
- second and third degree atrioventricular block
- bradycardia with heart rate ≤50/min
- pacemaker
- renal or hepatic insufficiency
- emergency procedures
- history of serious mental illness, delirium, and severe dementia
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Interventions
Upon arrival to the intensive care unit after open heart surgery, the patients will be sedated with continuous dexmedetomidine infusion in doses 0.2-0.7 mcg/kg/h.
Upon arrival to the intensive care unit after open heart surgery, the patients will be sedated with continuous propofol infusion in doses 1-2 mg/kg/h.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05849597