Virtual Reality Cognitive Intervention for Critically Ill Delirium Survivors (VR-Cog)
Indiana University
100 participants
Mar 19, 2026
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to measure the feasibility, acceptability of virtual reality (VR) brain games and estimate their effect on memory, attention, and mood for ICU survivors. The VR program will be used at home through a headset and hand controls.
Eligibility
Inclusion Criteria4
- Adults aged 50 years or older
- English speaking
- Admitted to the intensive care unit (ICU) with acute respiratory failure/invasive mechanical ventilation
- Screening positive for delirium (using Richmond Agitation Sedation Scale and Confusion Assessment Method for the ICU)
Exclusion Criteria10
- Acute neurologic injury such as stroke, traumatic brain injury, brain mass, intracranial hemorrhage, seizures, or central nervous system infection
- Chronic cognitive or physical function deficit preventing participation in study interventions or assessments (determined by chart diagnoses and direct participant interview)
- Chronic cognitive impairment (including mild cognitive impairment or dementia) identified by chart diagnosis, prescription of anti-dementia medications, or Informant Questionnaire on Cognitive Decline in the Elderly Score (IQCODE) >3.3 obtained from family caregiver
- Severe, uncorrected vision or hearing impairment preventing participation in intervention or outcomes assessments
- Admitted with acute alcohol or drug intoxication or withdrawal
- Severe, uncontrolled psychiatric disorder (bipolar disorder or schizophrenia)
- History of severe vertigo, motion-induced sickness, headaches, light sensitivity, seizures, or prior intolerance of virtual reality (VR)
- Receiving comfort care measures or not expected to survive the hospitalization
- Prisoners or patients unable to provide consent
- Not expected to be discharged home from the hospital, or living more than 50 miles from the nearest recruitment site, or homeless
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
VR-Cog features HomeTown Bound, a suite of 18 modules organized into four training categories: attention, processing speed, memory, and visuospatial.
VR-AC consists of a library of 9 nature scenes (content provided by Nature Treks VR).
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07496255