RecruitingNCT06749483

The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?

The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units? Research on Human Tissue, Body Fluids, Neuropsychological Assessment and Brain Imaging

Sponsor

Jena University Hospital

Enrollment

100 participants

Start Date

Dec 27, 2024

Study Type

OBSERVATIONAL

Conditions

Sepsis Critical Illness Neurocognitive Deficit Intensive Care Unit Delirium Microbiome,immune Function, Critically Ill Infection in ICU

Summary

Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis. The proposal aims to combine holistic approaches with emerging experimental technologies to investigate the complex interactions between the gut microbiota and its host and assess the impact of specific bacterial communities on longevity and stress responses. A strong focus of this study will also be placed on microbiome dysbiosis and secondary impacts on short- and long-term brain dysfunction using clinical, laboratory and imaging procedures.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Age ≥ 18 years
One of the following criteria
Critically ill patients treated with meropenem or piperacillin/tazobactam started within the last 72 h
Critically ill patients without systemic antimicrobial therapy within the last 72 hours and an expected ICU length of stay of more than 3 days
Long-term survivors of sepsis, e.g. from pre-existing sepsis cohorts

Exclusion Criteria11

Inflammatory bowel disease
Major bowel resection
Selective decontamination of the oral and digestive tract
Oral vancomycin therapy
Immunocompromised patients
History of chemotherapy during the last 6 months.
Known travel history to countries to areas of high antimicrobial resistance (>5% according to the report of the European Centre for Disease Prevention and Control and all countries except USA and Canada) within the last 4 weeks
Acute neurological diseases (e.g., brain ischemia, hemorrhage, meningoencephalitis, tumor)
Manifest dementia, pre-existing psychiatric diseases (schizophrenia, psychosis)
Acute brain surgery
MRI contraindications: pacemakers, hearing aids, neurostimulation, insulin pumps, other potentially ferromagnetic implants, screws, clips, prostheses, metal splinters, etc., pregnancy, claustrophobia, extensive tattoos.