RecruitingNot ApplicableNCT05854160

Stimulation-Induced Changes in Fronto-Limbic Network

Stimulation-Induced Changes in Fronto-Limbic Connectivity Control Regulation of the Emotional Response to Threat

Sponsor

University of Alabama at Birmingham

Enrollment

30 participants

Start Date

Mar 1, 2023

Study Type

INTERVENTIONAL

Conditions

Epilepsy Mental Disorders

Summary

The purpose of this research is to better understand how emotion processing unfolds in the brain using stereoelectroencephalography (sEEG) and direct brain stimulation. This study will use standard behavioral emotion processing tasks combined with neural recording and direct brain stimulation to assess different aspects of emotion processing. Stimulation pulses during pre and post-test periods will assess the effects of stimulation before and after conditioning, the results of which will be combined with results from the activity of each electrode during the emotion tasks to inform us of the nature of emotion processing in the brain and allow us to devise brain modulation protocols in the future.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how electrical stimulation of specific brain regions — particularly the front of the brain and the emotional center (amygdala) — affects brain network activity. It is conducted in patients who already have electrodes implanted in their brain as part of evaluation for epilepsy surgery. **You may be eligible if...** - You already have depth electrodes (sEEG) implanted in your brain for epilepsy evaluation - Your implanted electrodes are positioned in the amygdala and the medial prefrontal cortex regions of the brain - You are cognitively able to perform simple tasks and follow instructions - You can understand and sign an informed consent form **You may NOT be eligible if...** - You are unable to complete the required tasks during the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREElectrical Pulse Train Stimulation

sEEG provides the ability to stimulate neural circuits via implanted electrodes by delivering mild intra-cranial electrical stimulations in different brain structures to estimate their impact on cognitive tasks.