RecruitingNot ApplicableNCT05854368

Circulating Biomarker Signatures for the Detection of Gastric Preneoplasia and Cancer

Sponsor

Institut Pasteur

Enrollment

2,500 participants

Start Date

Jul 3, 2023

Study Type

INTERVENTIONAL

Conditions

Gastric Cancer Gastric Lesion Gastric Precancerous Condition

Summary

The goal of this study is to characterize and validate a signature of circulating biomarkers in plasma, associated with the presence of gastric preneoplasia in patients with preexisting gastric lesion compared with a control group. For this purpose: * Patients with pre-existing gastric lesions will be invited to participate to this study. If they are willing to participate an additional blood sample (9 mL) will be collected at the time of the blood collection performed during their routine care * Healthy subjects will be invited to participate to constitute the control group. If they are willing to participate a blood sample (9 ml) will be drawn specifically for this study

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial looks for blood-based biological markers (biomarkers) that can detect early stomach (gastric) cancer or pre-cancerous stomach conditions before symptoms appear. You may be eligible if... - You are 18 years or older - You have provided written informed consent - You are affiliated with a social insurance system - You have been diagnosed with untreated stomach tissue changes (atrophy, intestinal metaplasia, or dysplasia) or early gastric cancer not yet treated - OR you are a healthy volunteer without a known history of stomach infections or lesions You may NOT be eligible if... - You have an autoimmune disease or condition that affects your immune system (e.g., HIV) - You have a chronic inflammatory condition - You have another known active cancer (besides gastric cancer) - You have received immune-suppressing treatment in the last 3 months - You are on long-term corticosteroids or anti-inflammatory drugs - You are pregnant or breastfeeding - You are under legal guardianship, currently incarcerated, or enrolled in another clinical trial Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREAdditional blood collection as part of a blood sampling performed during routine care or specific for the research if not part of routine care.

Collection of an additional blood volume (9 mL) as part of a blood sampling performed during routine care or specific for the research if not part of routine care.

PROCEDUREBlood collection

Blood sample collection (10 mL)