RecruitingNot ApplicableNCT05865314

Optimised Nutritional Therapy and Early Physiotherapy in Long Term ICU Patients (NutriPhyT Trial)

Optimised Nutritional Therapy and Early Physiotherapy in Long Term ICU Patients: a Randomized Controlled Study (NutriPhyT Trial)

Sponsor

HEIDEGGER CP

Enrollment

164 participants

Start Date

May 1, 2023

Study Type

INTERVENTIONAL

Conditions

ICU acquired weakness Malnutrition Critical Illness

Summary

Due to medical advances and quality of care, mortality in adult intensive care units (ICUs) has decreased significantly in recent years, leading to a significant increase in the number of patients with high rehabilitation needs on discharge from the ICU. A specific management by a multidisciplinary team has been set up since 2017 at the Geneva-ICU for long-stay patients (hospitalised ≥ 7 days). This study aim to assess whether an optimization of the nutritional therapy coupled with an early mobility during and after the ICU stay allows an improvement in the muscle function at hospital discharge compared to patients receiving the standard care.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Any patient admitted to the adult ICU :
≥18 years old
On mechanical ventilation with an expected length of stay ≥ 7 days
Requiring artificial nutrition (enteral and/or parenteral nutrition)

Exclusion Criteria10

Therapeutic withdrawal Pregnant or breastfeeding patients
Neurological disorders with motor deficits:
New or pre-existing neuromuscular or nervous system disease
Spinal cord injury Severe polytrauma of the lower limbs (amputation etc.) Non-independent ambulation (including walking aids) before ICU admission
For organizational reasons not allowing follow-up :
Transfer to another ICU
Patient living abroad from Switzerland
Patient living in nursing homes preceding to ICU admission
Incarcerated patients
Intellectual/cognitive disabilities or language barrier, limiting ability to follow the instructions

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Interventions

OTHEROptimisation of nutrition therapy coupled with early mobilisation

Optimisation of nutrition therapy coupled with early mobilisation with: * Optimisation of nutrition therapy during ICU stay * Optimisation of physiotherapy during ICU stay * Better communication and closer collaboration between physiotherapy and nutrition teams. * Optimisation of continuity of the care.

OTHERStandard care

Patients will receive nutritional therapy and mobilisation according to local standard procedures.