A Study of Oncobax®-AK in Patients With Advanced Solid Tumors

This study tests Oncobax-AK, a probiotic-based treatment (using Akkermansia bacteria), in people with advanced non-small cell lung cancer or kidney cancer (clear cell type) to see if adding it improves how the immune system fights cancer. **You may be eligible if...** - You are over 18 years old with confirmed stage IV non-squamous lung cancer or clear cell kidney cancer - For lung cancer: your disease is stable (not progressing) and your tumor expresses high levels of PD-L1 (greater than 50%) - You do not have detectable Akkermansia bacteria in your stool - You are in good general health (ECOG 0–1) with at least one measurable tumor **You may NOT be eligible if...** - You have symptomatic brain metastases - You have active autoimmune disease requiring systemic treatment - You are currently on high-dose immune-suppressing steroids - You have had significant radiation to the lungs in the past 6 months - You are pregnant Talk to your doctor to see if this trial is right for you.