Neoadjuvant vs. Intraoperative vs. Adjuvant Resection Cavity Radiotherapy of Brain Metastases

This study is comparing three timing strategies for delivering stereotactic radiosurgery (precise, targeted radiation) for brain metastases that need surgical removal: before surgery, during surgery, or after surgery. The goal is to find the timing that best prevents cancer from coming back locally. **You may be eligible if...** - You have been diagnosed with a solid cancer that has spread to the brain (1–10 brain metastases) - At least one brain metastasis is in a non-critical location and is planned for surgical removal - The tumour is less than 5 cm in size - You are a candidate for both surgery and stereotactic radiosurgery **You may NOT be eligible if...** - You have more than 10 brain metastases - Your tumour is in a critical area of the brain (controlling speech or movement) that cannot be safely approached - You are not able to undergo both surgery and radiation Talk to your doctor to see if this trial is right for you.