Optical Biopsy for Peritoneal Nodules in Colorectal Patients
Use of Probe-based Confocal Laser Endomicroscopy to Perform Optical Biopsy for Peritoneal Nodules in Colorectal Cancer Patients During Surgery
Nanfang Hospital, Southern Medical University
278 participants
Sep 15, 2022
INTERVENTIONAL
Summary
During surgery, peritoneal metastasis is typically confirmed pathologically through resection sample. However, this process can be time-consuming when utilizing intro-operative frozen section pathology. To address this issue, we propose utilizing confocal laser endomicroscopy to provide in situ, real-time, and in-vivo diagnosis of suspected peritoneal nodules as cancer metastasis during surgery.
Eligibility
Inclusion Criteria5
- Age from over 18 to under 85 years
- American Society of Anesthesiology (ASA) score class I,II,or III
- Colorectal cancer
- Patients who be about to undergo surgical treatment
- Written informed consent
Exclusion Criteria4
- Pregnant or lactating women
- Acute renal insufficiency or stage II to IV chronic renal insufficiency
- Patients with severe liver damage
- Asthma patients or patients with allergic constitution
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Interventions
After intravenous injection of fluorescein sodium, pCLE-based optical biopsy will be performed.
Locations(1)
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NCT05879783