IDOV-Immune for Advanced Solid Tumors

This study is testing an experimental treatment called IDOV-Immune, a type of modified virus (oncolytic virus) that is designed to enter and destroy cancer cells, in people with advanced solid tumors that have stopped responding to standard therapies. **You may be eligible if...** - You are 18 or older - You have an advanced solid tumor confirmed by biopsy that has progressed despite standard treatment, or for which no standard treatment exists - You are in good overall health (ECOG 0–1) - Your tumor is measurable on imaging - Your organ function and bone marrow are adequate - At least 28 days have passed since major surgery, prior immunotherapy, or radiation **You may NOT be eligible if...** - You have received a prior oncolytic virus treatment - You have had a recent smallpox or monkeypox vaccination or active vaccinia virus infection - You are pregnant or not using effective contraception Talk to your doctor to see if this trial is right for you.