RecruitingNot ApplicableNCT05880108

Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation

Sponsor

VA Office of Research and Development

Enrollment

150 participants

Start Date

Jun 3, 2024

Study Type

INTERVENTIONAL

Conditions

Obesity Post-COVID Conditions

Summary

The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery.

Eligibility

Max Age: 80 Years

Inclusion Criteria3

U.S. Veteran
Self-reported COVID-19 naïve or COVID-19 > 90 days ago for lean and obese PCC naïve or documented COVID-19 for the lean and obese PCC groups (At least one PCC symptom >4 weeks)
Body Mass Index: 19-25 or 30-50 kg/m2

Exclusion Criteria6

Neurologic, musculoskeletal, or other condition that limits subject's ability to complete study physical assessments
Active inflammatory, COVID-19, autoimmune, infectious, hepatic (LFTs > 2.5 x WNL), renal (eGFR<45), gastrointestinal, malignant, and psychiatric disease
Uncontrolled diabetes (HbA1c >10% or the current use of insulin)
Weight change within the past month of >5 kg
Self-reported alcohol or drug abuse
Anti-coagulant medication usage

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BEHAVIORAL12-weeks of Weight Loss

Participants will be asked to participate in a 1x/week center-based or tele-health nutrition diet class, 2x/week center-based exercise classes, and 1x/week exercise session conducted on their own for \~12 weeks.

BEHAVIORAL12-weeks of Weight Stability

Participants will be asked to participate in a 1x/week center-based or tele-health education class, 2x/week center-based stretching/balance classes, and 1x/week stretching/balance session conducted on their own for \~12 weeks.