Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes
Treatment of Epilepsy Syndromes of Childhood With Sleep Activation Using Sulthiame: an Exploratory Study of the Short Term Effect on EEG
University Hospital, Angers
15 participants
Oct 17, 2023
OBSERVATIONAL
Conditions
Summary
The effect of sulthiame on EEG has been studied in epilepsy syndromes of childhood with sleep activation by comparing sleep EEG obtained at baseline and after 4 weeks of treatment. The aim of the study is to know if an effect is still identifiable after 2 weeks of treatment by performing sleep EEG recordings after 2 and 4 weeks of treatment, respectively.
Eligibility
Inclusion Criteria3
- Diagnosis of epilepsy syndromes of childhood with sleep activation
- Failure of at least two anti-epileptic drugs (AED)
- Sleep EEG performed in the last 7 days before inclusion and showing interictal epileptiform discharges (baseline EEG)
Exclusion Criteria4
- Previous trial with sulthiame
- More than 2 AED at inclusion
- Use of corticosteroids at inclusion
- Change in the anti-epileptic treatment in the 7 days before baseline EEG
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Interventions
Sulthiame add-on according to good clinical practice in these childhood epilepsy syndromes
Locations(3)
View Full Details on ClinicalTrials.gov
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NCT05885646