RecruitingNot ApplicableNCT05887661

Goal-directed LCVP Based on HP in Laparoscopic Hepatectomy

The Application of Goal-directed Low Central Venous Pressure Based on Hypovolemic Phlebotomy in Laparoscopic Hepatectomy

Sponsor

The First Affiliated Hospital with Nanjing Medical University

Enrollment

100 participants

Start Date

May 1, 2022

Study Type

INTERVENTIONAL

Conditions

Hepatocellular Carcinoma

Summary

The goal of this clinical trial is to learn about goal-directed LCVP based on hypovolemic phlebotomy (HP) in laparoscopic hepatectomy. The main questions it aims to answer are: 1. The safety and feasibility of HP 2. To evaluate whether HP can reduce perioperative blood transfusion ratio Participants undergoing liver resection with HP was performed by the anesthesiologist. Blood was withdrawn approximately 30 min prior to the initiation of liver parenchymal transection from central venous. The aim was to maintain the CVP between 0 to 5 cmH2O. HP volume was 5-10 mL/kg of patient body weight, generally. Participants in control group undergoing liver resection without HP.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a technique for managing blood volume during laparoscopic liver surgery (keyhole surgery to remove part of the liver) using real-time heart monitoring to guide fluid management and reduce blood loss. **You may be eligible if...** - You have been diagnosed with hepatocellular carcinoma (liver cancer) - You are scheduled for laparoscopic (keyhole) liver surgery and prefer this approach - You are 18 years old or older **You may NOT be eligible if...** - You are under 18 years old or pregnant - You refuse blood transfusions - You have active heart conditions (unstable angina, heart failure, serious arrhythmias, or severe valve disease) - You have significant lung, kidney, or blood clotting problems - Your liver function is severely impaired - Your hemoglobin (red blood cell count) is too low before surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREhypovolemic phlebotomy

hypovolemic phlebotomy was performed after induction of anesthesia and before the star of parenchymal division, with a goal-directed low central venous pressure drop to 5mmHg.