RecruitingPhase 2NCT05889741

Combining Stellate Ganglion Block With Prolonged Exposure for PTSD

Combining Stellate Ganglion Block With Prolonged Exposure for PTSD: A Randomized Clinical Trial


Sponsor

The University of Texas Health Science Center at San Antonio

Enrollment

140 participants

Start Date

Feb 26, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to compare the combination of Massed Prolonged Exposure (PE); a behavioral therapy for PTSD) and a stellate ganglion block (SGB; an injection of a local anesthetic into the front of the neck) with Massed Prolonged Exposure and a sham injection in a sample of military service members or retirees with PTSD. The main questions it aims to answer are: (1) Does the addition of an SGB improve treatment outcomes associated with Massed PE and (2) Do differences in psychophysiological arousal during the exposure portion of treatment help explain treatment outcomes for PTSD. Participants will receive ten 90-minute session of Massed PE. Between the first and second Massed PE sessions, half of the participants will receive a SGB, and half will receive a sham SGB.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study combines a nerve-block injection near the neck (stellate ganglion block) with an established trauma therapy called Prolonged Exposure to see if together they work better for PTSD in military personnel. **You may be eligible if...** - You are active duty or retired military, aged 18–65 - You have been diagnosed with PTSD by a clinician using a standardized assessment - You can read and speak English - You are enrolled in the military health system (DEERS) **You may NOT be eligible if...** - You are not affiliated with the military - You cannot communicate in English - You do not meet clinical PTSD criteria Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGRopivacaine injection

6.5cc of Ropivacaine hydrochloride (HCl) 0.5%, one time into the stellate ganglion

DRUGNormal saline

6.5cc of Normal Saline one time into the stellate ganglion.


Locations(2)

Carl R. Darnall Army Medical Center

Fort Hood, Texas, United States

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

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NCT05889741


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