RecruitingNot ApplicableNCT05890781

Engineering Immune Organoids to Study Pediatric Cancer

Engineering Immune Organoids to Study Pediatric Cancer (IMMUNE-ORGANOIDS)


Sponsor

Gustave Roussy, Cancer Campus, Grand Paris

Enrollment

108 participants

Start Date

May 12, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

To engineer immune organoids from pediatric patient tissues using induced-pluripotent stem cells (iPSC)


Eligibility

Max Age: 25 Years

Plain Language Summary

Simplified for easier understanding

This study collects tumor samples from children and young adults with cancer to build "immune organoids" — tiny lab-grown models of the immune system — to better understand how pediatric cancers interact with the immune system. **You may be eligible if...** - You are 25 or younger at the time of cancer diagnosis (no upper age limit for brain tumors or kidney tumors) - You have been diagnosed with or are suspected of having a brain tumor, kidney tumor, neuroblastoma, sarcoma, or related pediatric cancer **You may NOT be eligible if...** - You are an adult without one of the specific cancer types listed - You are unwilling to provide tissue samples Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURESkin biopsy

Skin biopsy

PROCEDUREFresh tumor sample

Fresh tumor sample

BIOLOGICALBlood sample

Blood sample in heparin tubes (highly recommended), to be collected before starting treatment or as soon as hematological recovery has been reached

PROCEDUREHealthy tissue from the tumor

Healthy tissue from the tumor site whenever possible

PROCEDURESpinal cerebrospinal fluid (SCF)

Spinal cerebrospinal fluid (SCF) whenever possible


Locations(2)

Gustave Roussy

Villejuif, France

Hopital Necker

Paris, Île-de-France Region, France

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NCT05890781


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