RecruitingNot ApplicableNCT05894980

How to Reduce Suicidal Thoughts and Impulsivity in Depression

Controlled Randomized Non-comparative Trial Assessing Active Transcranial Direct Current Stimulation [tDCS] on Left Dorsoleteral Prefrontal Cortex Versus Active tDCS Active on Right Orbitofrontal Cortex to Treat Unipolar Depression

Sponsor

Centre Hospitalier Universitaire de Besancon

Enrollment

100 participants

Start Date

Sep 1, 2023

Study Type

INTERVENTIONAL

Conditions

Unipolar Depression Suicidal Ideation Impulsive Behavior

Summary

The study aims at investigating if tDCS applied to left DLPFC or to right OFC to treatment as usual is effective in reducing severe suicidal ideas in major depressive episode.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates brain activity in people with major depression who have suicidal thoughts and high impulsivity, looking for biological patterns that might explain these symptoms and guide better treatments. **You may be eligible if...** - You are 18 or older and right-handed - You have a diagnosis of Major Depressive Disorder (MDD) confirmed using DSM-5 criteria - You are an inpatient or outpatient at an Adult Psychiatry Service in France - You are enrolled in the French social security system **You may NOT be eligible if...** - You are not right-handed - You are not currently diagnosed with MDD - You are not connected to a French social security system Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEactive tDCS stimulating left DLPFC

20 active tDCS sessions (4 sessions/day for 5 days, 30 min each, 2 mA) applied to the left DLPFC

DEVICEactive tDCS stimulating right OFC

20 active tDCS sessions (4 sessions/day for 5 days, 30 min each, 2 mA) applied to the right OFC

DEVICEsham tDCS

20 active tDCS sessions (4 sessions/day for 5 days, 30 min each, 0 mA) applied to the left DLPFC

Locations(4)

CHU de Besançon

Besançon, France

CHU de Clermont-Ferrand

Clermont-Ferrand, France

Hôpital Chenevier, GH Henri Mondor

Créteil, France

CHU de Montpellier

Montpellier, France

View Full Details on ClinicalTrials.gov

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NCT05894980

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