RecruitingPhase 1NCT06085937

Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department

Feasibility and Safety of Single Dose Ketamine for Acutely Suicidal Patients in the Emergency Department

Sponsor

Lindsay Maguire, MD

Enrollment

50 participants

Start Date

May 1, 2024

Study Type

INTERVENTIONAL

Conditions

Depression Suicide Suicidal Ideation

Summary

There is currently no readily available pharmacologic intervention for suicidal ideation, a true psychiatric emergency, in the Emergency Department (ED). Investigators aim to trial low-dose, intravenous ketamine, a drug with well-established use in treatment-resistant depression, for patients who present to the ED with suicidal ideation.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria5

Acutely Suicidality ("yes" answer to any of items 4 or 5 on C-SSRS "Suicidal Ideation" category)
Require inpatient stabilization for SI or actions based on clinical observation and interview
Are accepted for psychiatric stabilization at the University of Kansas Medical Center's Strawberry Hill campus
Have a Glasgow Coma Score (GCS) of 15
Age 18-65

Exclusion Criteria13

Current or past history of psychosis
Current or recent (past 4 weeks) symptoms of mania/hypomania as defined by Young Mania Rating Scale (YRMS) score of 12 or greater
History of ketamine use disorder
History of liver transplant
Pregnancy or breastfeeding
Imprisonment or inability to consent
Positive urine drug screen or serum alcohol level
Hypertension (SBP \> 160 or DBP \> 100 before administration of ketamine)
Hypotension (SBP \< 90)
Presence of acute medical condition requiring admission to medical service
Allergy, intolerance, or previous adverse reaction to ketamine
Patient has 8+ lifetime ketamine exposures
The treating physician determines that the patient is not a good candidate for the study (e.g. medical condition/procedure, medication that would contradindicate ketamine treatment)