RecruitingNCT05903066

TRansmural hEaliNg Definition in CroHn's Disease (TRENCH 1)

TRansmural hEaliNg Definition in CroHn's Disease - The TRENCH1 Study


Sponsor

Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives

Enrollment

210 participants

Start Date

Sep 28, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

Multicenter prospective cross-sectional study of CD patients, its aim is the construction of an objective and reproducible system for evaluation of Transmural healing in Crohn's Disease (CD). Primary objective : Objective definition of depth or grade of transmural healing in relation to radiologic signs observed during Magnetic Resonance Enterography (MRE) in CD


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is defining and measuring "transmural healing" in Crohn's disease — a deep level of bowel wall healing visible on MRI scans — to better understand if this type of healing correlates with better long-term outcomes than just surface-level healing (visible on colonoscopy). **You may be eligible if...** - You are 18 or older - You have had Crohn's disease for more than 6 months, confirmed by tissue biopsy - You are already scheduled for a bowel MRI scan (MRE) as part of your routine care - You are on any type of Crohn's treatment (biologics or immunosuppressants) **You may NOT be eligible if...** - You are pregnant - You have ulcerative colitis or unclassified IBD (not Crohn's disease) - You have had specific bowel surgeries (such as ileostomy or colostomy) - You are unable to give written consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

PROCEDUREMagnetic Resonance Enterography (MRE)

MRE performed as part of the standard of care follow up of the patient, the exam will be recorded for the study and analysed by central readers.


Locations(18)

CHU de Liège

Liège, Belgium

CHU Amiens-Picardie (site Sud)

Amiens, France

CHU de Bordeaux - Hôpital Haut-Lévêque

Bordeaux, France

APHP - Hôpital Ambroise Paré

Boulogne-Billancourt, France

CHU de Clermont-Ferrand - Hôpital d'Estaing

Clermont-Ferrand, France

APHP - Hôpital Louis Mourier

Colombes, France

CHRU de Lille - Hôpital Claude Huriez

Lille, France

CHU Limoges Dupuytren

Limoges, France

AP-HM - Hôpital Nord

Marseille, France

CHU de Montpellier - Hôpital Saint Eloi

Montpellier, France

CHU de Nantes

Nantes, France

CHU de Nice - Hôpital l'Archet II

Nice, France

CHU de Nîmes - Hôpital Carémeau

Nîmes, France

APHP - Hôpital Européen Georges Pompidou (HEGP)

Paris, France

Hospices Civils de Lyon

Pierre-Bénite, France

CHU Rennes - Hôpital Pontchaillou

Rennes, France

CHU de Saint Etienne - Hôpital Nord

Saint-Priest-en-Jarez, France

CHRU de Nancy - Hôpitaux de Brabois

Vandœuvre-lès-Nancy, France

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05903066


Related Trials