RecruitingNot ApplicableNCT05913713

HIIT Following Breast Cancer Chemotherapy

High Intensity Interval Training: Optimizing Exercise Therapy to Mitigate Cardiovascular Disease Risk Following Breast Cancer Chemotherapy

Sponsor

University of Florida

Enrollment

158 participants

Start Date

Mar 7, 2024

Study Type

INTERVENTIONAL

Conditions

Breast Cancer

Summary

Chemotherapy is an effective breast cancer treatment, which helped to increase the 5-year survival rate to approximately 95%. However, breast cancer survivors have a higher risk of cardiovascular disease (CVD) due to chemotherapy than adults without cancer. Cardiovascular rehabilitation can be an effective strategy to decrease the incidence of CVD and its risk factors in this population. The proposed study may help to examine the effect and durability of a novel high-intensity interval training compared to moderate-intensity continuous training on cardiovascular rehabilitation in breast cancer survivors.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether high-intensity interval training (HIIT) — short bursts of intense exercise — can help women recover from the physical effects of breast cancer chemotherapy, including fatigue and reduced fitness. **You may be eligible if...** - You are a woman aged 18–85 - You have had stage I–III breast cancer (non-metastatic) - You completed chemotherapy (anthracycline, alkylating agent, or taxane) between 6 months and 18 months ago - You are not currently exercising intensely on a regular basis **You may NOT be eligible if...** - Your breast cancer has spread to other organs - You finished chemotherapy less than 6 months ago or more than 18 months ago - You have heart conditions, joint problems, or other issues that make high-intensity exercise unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BEHAVIORAL12-week Intervention Period

Research participants will be randomly assigned to either high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), or the usual care (UC) group for a 12-week intervention period.

BEHAVIORAL12-week Observation Period

After a 12-week intervention period (HIIT, MICT, or UC), research participants will have a 12-week observation period to assess the durability of two types of different exercises.

Locations(1)

Integrative Cardiovascular Physiology Laboratory, University of Florida

Gainesville, Florida, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05913713

Related Trials

Genomic Services Research Program

NCT025959571 location

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

NCT052833304 locations

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer

NCT06103864316 locations

Social and Environmental Determinants of Breast Cancer Survivorship: the Black Breast Cancer Survivor's Intervention (BBCSI)

NCT068852031 location

A Synthetic Lethality-Focused Algorithm to Identify Therapeutic Options in Advanced Metastatic Breast Cancer (SYNTHESIS-Breast)

NCT070671381 location