Peer-led Implementation of TB-HIV Education and Adherence Counseling in Uganda
Yale University
1,920 participants
Mar 16, 2026
INTERVENTIONAL
Conditions
Summary
This cluster-randomized trial in Uganda will evaluate the effectiveness and implementation of a novel, peer-led TB education and counseling strategy to improve outcomes among persons with tuberculosis (TB) with and without HIV/AIDS and assess the social-behavioral mechanisms underlying the observed treatment effects.
Eligibility
Inclusion Criteria4
- Age ≥18 years
- Registered as a new, relapse, treatment failure, or previously lost-to-follow-up
- TB case according to the on-site NTP TB Treatment Register
- Screened and invited to participate within 30 days of TB treatment initiation
Exclusion Criteria4
- Diagnosed with possible or confirmed drug-resistant TB
- Transferring TB care into the clinic from an off-site facility
- Residing \>40 km from the enrolling clinic
- Lacking mental capacity to provide informed consent
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Interventions
Participants receive a peer-navigation strategy for TB education and counseling, including individual-level components such as peer navigator support, an illustrated TB-EC booklet with checklist, individualized adherence planning, and behavior-change messaging; and clinic-level components such as task-sharing with peer navigators, workflow restructuring, community of practice meetings, and implementation champions to support delivery.
Participants receive usual TB education and counseling delivered by healthcare workers, including individual-level components such as TB-HIV education using a flipchart and use of treatment supporters; and clinic-level components such as routine TB-EC delivery by healthcare workers.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05917210