RecruitingNot ApplicableNCT05921786
Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling-Establish Reliably Electrophysiological Readouts From Human-induced Pluripotent Stem Cells (hiPSCs)-Derived Cerebral Organoids and Surgically Dissected Human Live Brains
Sponsor
National Taiwan University Hospital
Enrollment
500 participants
Start Date
May 1, 2023
Study Type
INTERVENTIONAL
Conditions
Summary
The research aims to establish a big database of multiple kinds of brain tissues and prove the relevance of human brain tissue models and hiPSCs-derived organoid models.
Eligibility
Min Age: 18 Years
Inclusion Criteria1
- \. Patients older than the age of 18 with diagnosis of brain disease (both newly-diagnosed or recurrent) who are suitable and willing to receive resection surgery.
Exclusion Criteria4
- Patients who cannot give consent to participate in the study.
- The tumor samples failed to give a conclusive pathological diagnosis by standard pathological workflow.
- Patients who only receives biopsy surgery rather than resection surgery.
- Significant post-irradiation effect or radiation necrosis reported in the pathological examination.
Interventions
DEVICEElectrophysiological system
Electrophysiological system is used for examining voltage variation in biological samples. And multiphoton microscopy is a common type of nonlinear optical microscope.
DEVICEMultiphoton microscope
Multiphoton microscope acquires high-resolution image based on nonlinear optics and can be used for detect biological specimens.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05921786
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