Cognitive Neurology Unit Clinical Registry

This is a clinical registry — a long-term data collection study — for people with mild cognitive impairment (MCI) or early Alzheimer's disease who are being evaluated and followed at a specialized memory clinic. The registry collects detailed clinical information over time to better understand how these conditions progress and to evaluate treatments. **You may be eligible if:** - You have mild cognitive impairment or early (not moderate or advanced) dementia from Alzheimer's disease, confirmed by cognitive testing - You have a positive amyloid PET scan or abnormal spinal fluid results consistent with Alzheimer's disease - You have had a brain MRI in the past 6 months - You have a care partner (family member or friend who can provide support and information) - You are a patient at the appropriate clinic (BI-Lahey amyloid clinic) - You are on a stable medication regimen **You may NOT be eligible if:** - You have had a recent stroke or TIA (mini-stroke) in the past year - You are pregnant - You have an active autoimmune condition or are on immunosuppressant medications - You have a bleeding disorder or are on blood thinners (warfarin, heparin, DOACs, or dual antiplatelet therapy) - Your dementia is caused by something other than Alzheimer's disease - You carry two copies of the ApoE e4 gene (a genetic risk factor for Alzheimer's) Talk to your doctor to see if this trial is right for you.