Effects of Cryotherapy on Taxane-Induced Neuropathy in Patients With Breast Cancer

This study tests whether using cold therapy (cryotherapy — like cooling gloves or socks) during weekly paclitaxel chemotherapy infusions can prevent or reduce nerve damage (tingling, numbness, or pain in the hands and feet) that this drug commonly causes. **You may be eligible if...** - You have early-stage breast cancer - You are scheduled to receive weekly paclitaxel chemotherapy (12 or 9 doses at 80mg/m²) - Your general health (performance status) is 0 or 1 **You may NOT be eligible if...** - You already have nerve damage (neuropathy, pain, or swelling) in your limbs at grade 2 or higher - You have Raynaud's syndrome (a condition where cold causes blood vessel spasms) - You have peripheral arterial ischemia (reduced blood flow to the limbs) - Your doctor determines that cold therapy is not safe for another medical reason Talk to your doctor to see if this trial is right for you.