Impulsivity Domains and Subjective Response
Linking Impulsivity Domains and Subjective Response to Alcohol in Young Adults Using Lab and Daily Assessment Methods
Jessica Weafer
250 participants
Apr 1, 2024
INTERVENTIONAL
Conditions
Summary
Findings from this project will determine the relationship between two vulnerability factors for Alcohol Use Disorder (AUD) in young adults: impulsivity and subjective response to alcohol. The results will identify badly needed, novel targets for prevention and treatment efforts to simultaneously reduce impulsivity and subjective responses in at-risk young adults.
Eligibility
Inclusion Criteria4
- -25 years old
- Report drinking to an estimated BAC > .08% at least once in the past 30 days based on responses on the Timeline Followback (TLFB)
- Report drinking at least twice weekly in the past 30 days based on responses on the TLFB
- Fluency in English
Exclusion Criteria11
- Any serious medical problems (e.g., liver disease, cardiac abnormality, pancreatitis, diabetes, neurological problems, and gastrointestinal disorders)
- Body weight < 110 or > 210 pounds
- Axis I psychiatric disorders including substance use disorder other than mild or moderate alcohol or mild cannabis use disorder
- Current alcohol withdrawal or history of medically-assisted detoxification
- Two positive breath alcohol concentration (BrAC) readings (i.e., > 0.00%) at an in-person screening appointment or experimental session
- Positive urine screen for illegal drugs other than cannabis
- Currently seeking or past-12-month history of inpatient or intensive treatment for addictive behaviors
- Current psychotropic medication use or receipt of a prescription for these medications in the past 30 days
- Psychosis or other psychiatric disability
- Pregnancy, nursing or lack of reliable birth control use for women
- Report smoking > 5 cigarettes per day (to avoid acute nicotine effects or withdrawal during experimental sessions)
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Participants receive placebo (saline) intravenously. They will also have the opportunity to self-administer saline during the 60-minute free-access IV self-administration period in session 3.
Participants receive alcohol intravenously, clamped at BrACs of 20mg%, 40mg%, and 60mg%. They will also have the opportunity to self-administer alcohol (up to 120mg% BrAC) during the 60-minute free-access IV self-administration period in session 3.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05929677