RecruitingNot ApplicableNCT05929898

MRI Neurofeedback and Brain Circuits Related to Motivation in Healthy Participants

Bridging Scales to Understand Endogenous Neuromodulation and Its Regulation


Sponsor

Duke University

Enrollment

190 participants

Start Date

Jul 30, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this research study is to understand how healthy individuals self-regulate motivation by observing brain activity using magnetic resonance imaging (MRI).


Eligibility

Min Age: 18 YearsMax Age: 45 Years

Inclusion Criteria5

  • Age between 18 and 45 years
  • Male or female
  • Right-handed
  • In good general health
  • Women of childbearing capacity: use of effective method of birth control

Exclusion Criteria21

  • Current or diagnosis within past six months of an DSM-V Axis I or Axis II disorder (self-reported)
  • CES-D score of 20 or higher (indicating significant current depression symptoms)
  • Current or past six month use of prescription medications indicated for psychiatric conditions (e.g.,depression, anxiety)
  • Current serious medical illness (self-reported)
  • Head injury resulting in loss of consciousness
  • For participants age \> 59 years, a total scaled score \< 8 on the Dementia Rating Scale-2.
  • A clinically-defined neurological disorder including, but not limited to:
  • Any condition likely to be associated with increased intracranial pressure
  • Space occupying brain lesion
  • History of stroke
  • Transient ischemic attack within two years
  • Cerebral aneurysm
  • Dementia
  • Mini Mental Status Exam (MMSE) score of \<24
  • Parkinson's disease
  • Huntington's disease
  • Multiple sclerosis
  • Presence of cochlear implants or other implanted electronic devices or non-removable metal (e.g., non-removable piercing, IUD)
  • History of an eye injury involving metal. Participants who worked with metal may be allowed to participate on a case-by-case basis with prior written approval from BIAC.
  • Claustrophobia or unwillingness to tolerate the confinement associated with being in the MRI scanner.
  • Weight of more than 250 pounds

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Interventions

BEHAVIORALVentral tegmental area of dopaminergic midbrain (VTA) fMRI neurofeedback

fMRI neurofeedback training of sustained midbrain/VTA activation via motivational imagery.


Locations(1)

Center for Cognitive Neuroscience

Durham, North Carolina, United States

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NCT05929898


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