RecruitingPhase 3NCT05930210

A Study to Evaluate ENERGI-F703 GEL in Diabetic Foot Ulcer

A Randomized, Double-Blind, Vehicle-controlled, Parallel, Phase III Study to Evaluate Efficacy and Safety of ENERGI-F703 GEL in Subjects With Diabetic Foot Ulcers


Sponsor

Energenesis Biomedical Co., Ltd.

Enrollment

230 participants

Start Date

May 30, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This Phase 3 study is a randomized, double-blind, vehicle-controlled, multiple-center, parallel study to evaluate efficacy and safety of ENERGI-F703 GEL compared with vehicle control in subjects with Wagner Grade 1 to Grade 2 diabetic foot ulcers. Baseline target ulcer size (\<16 cm2 vs ≥16 cm2 ) will be included as a stratification factor. Subjects will be randomized 1:1 to receive ENERGI-F703 GEL or vehicle control using an interactive web response system for randomization to automatically assign a unique subject randomization number. Total duration of the study will be up to 31 weeks including Screening visit (approximately 2 to 3 weeks), double-blind dosing/observation phase (16 weeks), and a safety follow-up of 12 weeks after the last administration of study treatment.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called ENERGI-F703 GEL and a drug called ENERGI-F703 matched vehicle for people with diabetes mellitus, diabetic foot ulcer, and other related conditions. The study is currently recruiting participants at 24 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGENERGI-F703 GEL

Standard of care and ENERGI-F703 GEL are applied for the treatment of diabetic foot ulcers.

DRUGENERGI-F703 matched vehicle

Standard of care and ENERGI-F703 matched vehicle are applied for treatment of diabetic foot ulcers.


Locations(24)

A and D Doctor Center

Miami, Florida, United States

Bioclinical Research

Miami, Florida, United States

Reliant Medical Research

Miami, Florida, United States

Advanced Medical Research Institute

Miami, Florida, United States

New Horizons Research

Palmetto Bay, Florida, United States

IACT Health

Columbus, Georgia, United States

The Jackson Clinic PA

Jackson, Tennessee, United States

Mt. Olympus Medical Research

Houston, Texas, United States

Wasatch Clinical Research

Salt Lake City, Utah, United States

Salem Veterans Affairs Medical Center VAMC

Salem, Virginia, United States

Ditmanson Medical Foundation Chia-Yi Christian Hospital

Chiayi City, Taiwan

Kaohsiung Medical University Hospital

Kaohsiung City, Taiwan

China Medical University Hospital

Taichung, Taiwan

Kung Tien General Hospital

Taichung, Taiwan

Taichung Veterans General Hospital

Taichung, Taiwan

Chi Mei Medical Center

Tainan, Taiwan

National Cheng Kung University Hospital

Tainan, Taiwan

Cathay General Hospital

Taipei, Taiwan

MacKay Memorial Hospital

Taipei, Taiwan

National Taiwan University Hospital

Taipei, Taiwan

Shin Kong Wu Ho Su Memorial Hospital

Taipei, Taiwan

Taipei Veterans General Hospital

Taipei, Taiwan

Tri-Service General Hospital

Taipei, Taiwan

Linkou Chang Gung Memorial Hospital

Taoyuan, Taiwan

View Full Details on ClinicalTrials.gov

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NCT05930210


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