Sauna for Long Covid
A Pilot Study of Whole Body Hyperthermia for Long Covid or Post-Acute Sequelae of COVID-19 (PASC)
Massachusetts General Hospital
21 participants
Aug 1, 2026
INTERVENTIONAL
Conditions
Summary
Research suggests that Whole Body Hyperthermia in a sauna-like environment can reduce symptoms related to post-acute sequelae of SARS-CoV-2 (PASC), or Long Covid. The investigators aim to study the feasibility and treatment effect of this procedure for patients experiencing Long Covid symptoms.
Eligibility
Inclusion Criteria7
- 18-65 years of age
- English language proficiency
- Ability to provide informed consent
- Ability to lie supine (on back) for 2 hours (required for sauna sessions)
- Must have had clinically suspected COVID-19 and a positive antibody test or a documented SARS-CoV-2 infection (a positive reverse transcription polymerase chain reaction test) at least 12 weeks prior to Screening (Note: clinician judgment can override lack of positive COVID test with clear Long Covid onset and presentation)
- The Patient Reported Outcome Measurement Information System Fatigue-Short Form v1.0 -Fatigue 7a (PROMIS F-SF43) raw score of 21 or greater at Screening (onset of fatigue confirmed post-infection as in other studies of PASC)
- Individuals of childbearing potential must use an acceptable form of birth control.
Exclusion Criteria18
- Fatigue for known reasons other than PASC (e.g. longstanding diagnosis of Chronic Fatigue Syndrome pre-dating Long Covid, low thyroid, multiple sclerosis, AIDS related fatigue, mononucleosis), as determined by clinical discretion of study investigators
- Known hypersensitivity to infrared heat exposure, significant history of heat stroke
- Breastfeeding, pregnancy or planned pregnancy during study
- Active suicidal intent
- History of bipolar disorder, psychotic disorders, eating disorders, obsessive compulsive disorder, and/or substance use or dependence (within the last year), as per the Mini-International Neuropsychiatric Interview (MINI)44
- Positive urine toxicology screen for illicit drug use
- Any serious unstable medical condition
- Inability to fit into the sauna device. Morbid obesity (BMI > 40) and/or body shape that might increase the risk of cutaneous burning from the device (because of skin being too close to the heat).
- Back pain that would interfere with ability to lay on hard surface
- Using medication that might impact thermoregulatory capacity and cannot be held for an appropriate length (at least one half-life) as determined by clinician judgment prior to receiving WBH treatment
- Breast Implants
- Claustrophobia that would interfere with ability to remain in sauna
- Unsafe cardiac status as defined by abnormal ECG reading at screening visit or as determined by study doctor or subject's physician
- History of or current diagnosis of thrombosis or thrombophilia
- History of hemophilia
- History of febrile seizures or seizure disorders
- Any new treatments/medications for long-COVID that have started in the past 3 months
- A subject who in the opinion of the Principal Investigator would not be able to safely complete the study or would jeopardize study integrity.
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Interventions
heat will be applied to the participant through a sauna to increase core body temperature
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05931497