RecruitingNCT05933889

Single and Combined Modality Trans-Oral Robotic Surgery in Early Oropharyngeal Cancer

Single and Combined Modality Trans-Oral Robotic Surgery in Early Oropharyngeal Cancer: Exploring the Impact of Surgical Margins on Local Disease Recurrence: The SCORE Study


Sponsor

Royal Marsden NHS Foundation Trust

Enrollment

250 participants

Start Date

Dec 19, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

Multi-centre retrospective observational cohort study with optional exploratory radiomic study (international) and prospective molecular analysis studies (UK only).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is gathering long-term data on patients who had early-stage throat cancer (oropharyngeal cancer) treated with a robotic surgical technique called TORS (trans-oral robotic surgery). It aims to understand outcomes and side effects across different treatment approaches. **You may be eligible if...** - You are 18 or older - You had cancer in the oropharynx (tonsil, soft palate, tongue base, or oropharyngeal walls) - Your cancer was confirmed to be squamous cell carcinoma - You had early-stage cancer (pT1–T2) - You were treated with TORS (with or without additional therapy) on or before December 31, 2021 **You may NOT be eligible if...** - Your cancer was at a more advanced stage (T3–T4) - Your TORS was performed for diagnostic, recurrent, or palliative purposes only - You had a prior history of head and neck cancer or head/neck radiation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

GENETICMolecular Analysis

Germline and circulating tumour DNA analysis of buccal/ blood samples and molecular analysis of primary and recurrent tumour tissue samples

OTHERRadiomic/ Morphological analysis

Radiomic analysis and assessment of morphological features of pre-operative CT/ MRI imaging in patients who have undergone TORS for primary oropharyngeal cancer.


Locations(1)

The Royal Marsden Hospital NHS Foundation Trust

London, United Kingdom

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NCT05933889


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