RecruitingNot ApplicableNCT05939310

Fluorescence Guided Surgery in Breast Cancer - The MARGIN-2 Study

Improving Radical Resection Rates in Patients With Breast Cancer by Intraoperative Imaging Using Bevacizumab-IRDye800CW - the MARGIN-2 Study


Sponsor

University Medical Center Groningen

Enrollment

70 participants

Start Date

Jan 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to intraoperatively visualize tumour tissue in breast cancer patients using fluorescence imaging with the tracer bevacizumab-IRDye800CW and thereby enhance real-time clinical decision making, preventing postoperative tumour-positive margins.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study (MARGIN-2) is testing a fluorescence dye imaging technique during breast-conserving surgery (lumpectomy) to help surgeons see the edges of a tumor more clearly and ensure the entire cancer is removed. **You may be eligible if...** - You are female, 18 or older - You have been diagnosed with breast cancer confirmed by biopsy - Your cancer is localized (has not spread) and is at least 0.5 cm in size - Your treatment team has recommended breast-conserving surgery (keeping the breast) - You have consented to participate **You may NOT be eligible if...** - You require a full mastectomy (complete breast removal) - You are pregnant or breastfeeding - You have a known allergy to the fluorescent dye used - You have inflammatory breast cancer or other conditions that make the technique unsuitable Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREFluorescence guided detection of tumor positive margins.

Intraoperative fluorescence imaging detection of tumor positive margins using the targeted tracer bevacizumab-IRDye800CW.


Locations(2)

University Medical Center Groningen

Groningen, Netherlands

Martini Ziekenhuis

Groningen, Netherlands

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NCT05939310


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