RecruitingPhase 1NCT05942300

CPI-0209 Plus Carboplatin in Patients With Platinum Sensitive Recurrent Ovarian Cancer

Phase I Trial of CPI-0209 in Combination With Carboplatin in Patients With Platinum Sensitive Recurrent Ovarian Cancer


Sponsor

Lan Coffman

Enrollment

30 participants

Start Date

Jan 30, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is a clinical trial using CPI-0209 in combination with Carboplatin chemotherapy followed by CPI-0209 maintenance in patients with platinum sensitive, recurrent ovarian cancer.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing CPI-0209 (an EZH2 inhibitor, a drug that targets a gene-silencing protein in cancer cells) in combination with carboplatin chemotherapy for women with platinum-sensitive recurrent ovarian, fallopian tube, or peritoneal cancer. **You may be eligible if...** - You have ovarian, fallopian tube, or primary peritoneal cancer that has come back - Your cancer is "platinum-sensitive" — meaning it came back more than 6 months after your last platinum-based chemotherapy - You are eligible to receive platinum-based chemotherapy again - You have measurable disease on imaging or documented disease progression **You may NOT be eligible if...** - Your cancer came back within 6 months of platinum chemotherapy (platinum-resistant) - You have received too many prior lines of chemotherapy - You have active brain metastases - You have serious heart, liver, or kidney problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCPI-0209

A second-generation EZH2 inhibitor that has been designed to achieve comprehensive anti-cancer target coverage through extended on-target residence time.

DRUGcarboplatin

Carboplatin is a chemotherapy drug that contains the metal platinum. It stops or slows the growth of cancer cells and other rapidly growing cells by damaging their DNA.


Locations(1)

Magee-Womens Research Institute / UPMC Magee Womens Hospital

Pittsburgh, Pennsylvania, United States

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NCT05942300


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