HS-10502 Combination Treatment in Patients With Advanced Solid Tumors

This study is testing a new combination treatment called HS-10502 in people with advanced solid tumors (cancers that have spread or cannot be surgically removed). Researchers want to find out if this treatment is safe and effective. **You may be eligible if...** - You are 18 or older with an advanced solid tumor confirmed by biopsy - You have at least one measurable tumor on imaging - You are generally well enough to care for yourself (ECOG performance status 0-1) - You have a life expectancy of at least 12 weeks - You agree to use contraception during and for 6 months after treatment **You may NOT be eligible if...** - You have previously received PARP inhibitor, B7-H4, or B7-H3 targeted therapies - You received chemotherapy or other anti-tumor drugs in the past 2 weeks - You have brain metastases or cancer spread to the brain lining - You have active hepatitis B, hepatitis C, HIV, tuberculosis, or syphilis - You have severe heart, liver, kidney, or lung problems - You are pregnant or breastfeeding - You have an active autoimmune disease Talk to your doctor to see if this trial is right for you.