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RecruitingNCT05943262

Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling

Sponsor

National Taiwan University Hospital

Enrollment

100 participants

Start Date

May 1, 2023

Study Type

OBSERVATIONAL

Conditions

Brain TumorBrain Cancer

Summary

The research aims to develop a novel pathological technology, including rapid whole-mount tissue H\&E \& IHC staining protocol and high-resolution nonlinear optical microscopy imaging system, to intraoperatively assess brain tumor grade, types and other biological parameters.

Eligibility

Min Age: 20 Years

Inclusion Criteria1

  • \. Patients older than the age of 20 with diagnosis of brain tumor (both newly-diagnosed or recurrent) who are suitable and willing to receive resection surgery.

Exclusion Criteria4

  • Patients who cannot give consent to participate in the study.
  • The tumor samples failed to give a conclusive pathological diagnosis by standard pathological workflow.
  • Patients who only receives biopsy surgery rather than resection surgery.
  • Significant post-irradiation effect or radiation necrosis reported in the pathological examination.

Interventions

DEVICEmesoscale nonlinear optical microscope

The mesoscale nonlinear optical microscope based on the principles of nonlinear optics and computed-algorithms can acquire large-area image within few minutes.

Locations(1)

Department of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University

Taipei, Taiwan

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NCT05943262

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