RecruitingNCT05943652

Observational Study on "Functional Overlay" in Patients With Movement Disorders

Prevalence and Clinical Presentation of Functional Neurological Disorders in Patients With Movement Disorders - A Cross-sectional Study in the Movement Disorders Clinic of the Department of Neurology, Medical University of Graz

Sponsor

Medical University of Graz

Enrollment

216 participants

Start Date

Jan 1, 2023

Study Type

OBSERVATIONAL

Conditions

Parkinson Disease Dystonia Tremor Conversion Disorder

Summary

The goal of this observational study is to learn about functional neurological disorders in patients with common non-functional movement disorders ("functional overlay"). The main questions it aims to answer are: * What is the frequency of functional neurological disorders in patients with non-functional movement disorders (functional overlay)? * What are the characteristics of functional neurological disorders in patients with non-functional movement disorders? Participants will be examined clinically and electrophysiologically, the examinations consist of: * a neurological examination * neuropsychological testing * electrophysiological tremor diagnostic * questionnaires about psychological, biological and social risk factors Researchers will compare patients with functional motor disorders to patients wit non-functional movement disorders to see if they differ from each other regarding the functional symptoms.

Eligibility

Min Age: 18 YearsMax Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This observational study is looking at patients who have movement disorders — such as tremors, stiffness, or unusual movements — to better understand the overlap between physical neurological symptoms and psychological factors (called "functional overlay"). The aim is to improve diagnosis and care for people whose movement problems don't fully fit a single explanation. **You may be eligible if...** - You are between 18 and 80 years old - You have a movement disorder, whether neurological or functional (psychological) in origin **You may NOT be eligible if...** - You are unable to give consent - You cannot understand or speak German fluently (questionnaires are only available in German) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTNeurological examination

A neurological examination following a protocol to detect positive signs of functional neurological disorders.

DIAGNOSTIC_TESTAnamnesis

A standardized question about the patient´s history. The response time is measured. Question: "Could you tell me about the problems with the movement disorder you are experiencing?"

DIAGNOSTIC_TESTNeuropsychological testing

Neuropsychological cognitive testing including: * Montreal Cognitive Assessment (MOCA) * Rey-Osterrieth Complex Figure Test (ROCFT) * Wechsler Memory Scale IV * Comprehensive Trail Making Test (CTMT) * semantic and phonematic fluency tests

DIAGNOSTIC_TESTQuestionnaires

* Short Form 36 (SF 36) * Somatic Symptom Disorder - B Criteria Scale (SSD 12) * Patient Health Questionnaire 9 (PHQ 9) * Patient Health Questionnaire 15 (PHQ 15) * Generalized Anxiety Disorder 7 (GAD 7) * Fatigue Severity Scale (FSS) * Psychosomatic Competence Inventory (PSCI) * Work Ability Index (WAI) * Level of Personality Functioning Scale * Toronto Alexithymia Scale * Levels of Emotional Awareness Scale (short version) * Certainty About Mental States Questionnaire * Somatosensoric Amplification Scale * Personality Inventory for DSM-5 short version (PID5BF+M) * Childhood Trauma Questionnaire * European Quality of Life 5 Dimensions 5 Level Version (EQ5D5L)

DIAGNOSTIC_TESTTremor recording

Accelerometry following a standardized protocol, using a triaxial accelerometer transducer (Biometrics ACL300, Sensitivity 6 100 mV/G, Biometrics Ltd, UK)